Product Name: 5F-ADB (5F-MDMB-PINACA)
Catalog Number: V9646
CAS Number: 1715016-75-3
Molecular Formula: C20H28FN3O3
Molecular Weight: 377.45 g/mol
Purity: ≥99%
1. Product Overview
5F-ADB is a novel, potent indazole-based synthetic cannabinoid (SCRA) belonging to the indazole-3-carboxamide family. It is chemically defined as methyl (S)-2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate . First identified by forensic authorities in Japan in late 2014, this compound is exclusively utilized as a certified reference material for analytical and forensic toxicology applications.
2. Key Chemical Properties
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IUPAC Name: Methyl (S)-2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate
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Appearance: Typically exists as a solid at room temperature
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LogP: 4.2
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InChi Key: PWEKNGSNNAKWBL-UHFFFAOYSA-N
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Storage Conditions: Powder stable for 3 years at -20°C or 2 years at 4°C. In solvent, stable for 6 months at -80°C .
3. Pharmacological & Toxicological Profile
5F-ADB acts as a highly potent full agonist of the CB1 cannabinoid receptor. Toxicological data indicates it is significantly more potent than THC or earlier generation SCRA like MDMB-CHMICA, exhibiting a higher binding affinity in the low nanomolar range . Non-clinical studies have shown that exposure leads to CB1-mediated increases in dopaminergic neuron firing, correlating with severe adverse effects observed in intoxication cases .
4. Regulatory & Legal Status
Due to its high abuse potential and lack of accepted medical use, 5F-ADB is strictly controlled:
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United States: DEA Schedule I Controlled Substance .
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International: Recommended for placement in Schedule II by the WHO Expert Committee on Drug Dependence (ECDD) under the UN Convention on Psychotropic Substances of 1971 .
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Regional: Controlled as a banned substance in Japan (added Dec 2014), Canada (Schedule II), and Germany (Anlage II) .
5. Forensic & Research Applications
This product is intended for laboratory research, forensic analysis, and clinical toxicology only. Not for human or veterinary use.
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LC-MS/MS & GC-MS: Certified reference material for the detection of NPS in biological matrices and seized materials .
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Metabolite Identification: Used to identify specific metabolites (e.g., 5-fluoro ADB metabolite 2) in urine drug testing and post-mortem samples, which is critical as the parent compound is rapidly metabolized in blood .
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Urine Drug Testing: Serves as an analytical standard for confirming exposure in clinical settings.
6. Safety & Hazard Information (GHS)
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Hazard Statements: H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), H336 (May cause drowsiness or dizziness) .
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Signal Word: Danger / Warning.
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Precautionary Statements: Avoid breathing dust. Use only with adequate ventilation (P271). Wear protective gloves and eye/face protection (P280). Store locked up (P405)
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